To gain a big-picture view of naltrexone and acetaminophen combination for analgesia, we conducted four proof-of-concept clinical trials for the acute treatment of migraine, migraine prevention, and chronic low-back pain. We completed these studied in August 2018. For regulatory approval, we plan to focus on the acute treatment of migraine indication first, followed by the preventive treatment of migraine, chronic low back pain, and adjustment disorder. For more information, please visit clinicaltrials.gov